In order to carefully weigh the most appropriate risk management measures for a substance under REACH, all available information has to be considered. Especially substances that are used in innovative techniques and materials which will gain market maturity in foreseeable time it is of importance to consider potentially arising risks at an early stage. The research project generated a list of substances that matter amongst others in techniques such as 3D printing, organic semiconductors or photovoltaic and in materials like functional polymers.