This data documentation describes the Scientific Use File of the Study "Healthy digital work", which the Research Data Centre of the Federal Institute for Occupational Safety and Health (FDZ-BAuA) makes available to users for scientific research projects. This study was conducted as part of the joint project “Prevention for safe and healthy work with digital technologies” (PräDiTec), funded by the German Federal Ministry of Education and Research (BMBF). The scientific use file comprises 5,005 persons who were surveyed once between December 2018 and February 2019 in an online survey (Computer-Assisted Web Interview, CAWI) about digital stress in different industries and activities, coping with digital stress, and various aspects of health and work satisfaction. The sample is mainly composed of knowledge workers, with a smaller reference group of non-knowledge workers included. The data documentation provides an overview of the available data and documents the data edition process.